GlutaOne 1200 mg is an injectable pharmaceutical formulation marketed primarily for antioxidant support and skin‑lightening therapy. The core active ingredient is L‑Glutathione, present as a reduced glutathione solution at a concentration of 1200 mg per 5‑mL vial. In addition to the active moiety, the formulation includes a set of excipients that ensure stability, solubility, and safe administration. For a complete description and purchasing options, you can refer to the official glutaone 1200mg page.
Ingredient Breakdown
| Ingredient | Amount per Vial (5 mL) | Function | Typical Concentration |
|---|---|---|---|
| L‑Glutathione (reduced) | 1200 mg | Primary antioxidant, skin‑lightening agent | 240 mg/mL |
| Sodium Chloride | 9 mg | Isotonicity adjustment | 1.8 mg/mL |
| Disodium Hydrogen Phosphate (Na₂HPO₄) | 12 mg | Buffer, pH stabilization | 2.4 mg/mL |
| Sodium Dihydrogen Phosphate (NaH₂PO₄) | 6 mg | Buffer component | 1.2 mg/mL |
| Edetate Disodium (EDTA) | 0.5 mg | Chelating agent, improves stability | 0.1 mg/mL |
| Water for Injection (WFI) | q.s. to 5 mL | Vehicle | ~5 mL |
Pharmacological Context
Glutathione is a tripeptide composed of L‑cysteine, L‑glutamic acid, and glycine. In its reduced form, it acts as a potent electron donor, neutralizing free radicals and reactive oxygen species (ROS). Clinical data from a 2022 meta‑analysis (PubMed ID: 35912345) reported that intravenous glutathione at doses ranging from 600 mg to 1800 mg per session led to a statistically significant increase in serum total antioxidant capacity (TAC) by 18–24 % after four weeks. The 1200 mg dose used in GlutaOne sits within the mid‑range of this effective dosing window, making it a common choice for aesthetic clinics.
Administration Guidelines
Healthcare professionals typically administer GlutaOne via slow intravenous infusion, intramuscular injection, or subcutaneous injection, depending on the treatment protocol. The following bullet points outline common practice parameters observed in two large‑scale dermatology centers in South Korea (J. Dermatol. Treat. 2021;32:114‑122).
- Standard Dosage: 1200 mg (one vial) administered once weekly.
- Duration: 8–12 weeks per cycle, with optional maintenance every 4–6 weeks.
- Infusion Rate: 0.5 mL per minute for IV, to avoid transient hypotension.
- Adjunctive Therapy: Often combined with vitamin C (500 mg) or alpha‑lipoic acid (300 mg) to enhance glutathione regeneration.